The novelty of SALIVA+ relies on building a new paradigm in food contaminants exposure assessment to: i) offer to regulatory agencies and scientific community a reliable and non-invasive tool capable of assessing with precision humans’ exposure to a wide range of dietary contaminants; ii) deliver a multiorgan in vitro model to predict salivary:plasma distribution for other contaminants. The successful outcomes of this project will open the door to a different approach of risk assessment offering non-invasive measurements of well-known and emerging contaminants that will facilitate and hopefully increase the number of HBM studies worldwide.